home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-06 | 540.9 KB |
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MacOS 8.1
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Win98
|
DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
|00000000| 1a 44 50 31 2e 31 00 00 | 00 00 00 00 00 05 64 00 |.DP1.1..|......d.|
|00000010| 00 00 16 00 00 00 30 30 | 00 00 00 01 9c 05 00 00 |......00|........|
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|000003d0| 00 00 00 01 94 0e 05 00 | 66 27 00 00 36 39 00 00 |........|f'..69..|
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|00000410| 6b 19 00 00 37 33 00 00 | 00 01 b3 b7 05 00 91 0c |k...73..|........|
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|00000440| 00 00 00 01 d0 eb 05 00 | 23 21 00 00 37 37 00 00 |........|#!..77..|
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|00000470| 06 00 52 13 00 00 38 30 | 00 00 00 01 9f 3f 06 00 |..R...80|.....?..|
|00000480| ee 17 00 00 38 31 00 00 | 00 01 8d 57 06 00 74 25 |....81..|...W..t%|
|00000490| 00 00 38 32 00 00 00 01 | 01 7d 06 00 a5 28 00 00 |..82....|.}...(..|
|000004a0| 38 33 00 00 00 01 a6 a5 | 06 00 36 0c 00 00 38 34 |83......|..6...84|
|000004b0| 00 00 00 01 dc b1 06 00 | 22 1c 00 00 38 35 00 00 |........|"...85..|
|000004c0| 00 01 fe cd 06 00 00 22 | 00 00 38 36 00 00 00 01 |......."|..86....|
|000004d0| fe ef 06 00 e0 0c 00 00 | 38 37 00 00 00 01 de fc |........|87......|
|000004e0| 06 00 d7 2d 00 00 38 38 | 00 00 00 01 b5 2a 07 00 |...-..88|.....*..|
|000004f0| 7f 17 00 00 38 39 00 00 | 00 01 34 42 07 00 31 1d |....89..|..4B..1.|
|00000500| 00 00 39 30 00 00 00 01 | 65 5f 07 00 74 19 00 00 |..90....|e_..t...|
|00000510| 39 31 00 00 00 01 d9 78 | 07 00 1c 13 00 00 39 32 |91.....x|......92|
|00000520| 00 00 00 01 f5 8b 07 00 | 6c 25 00 00 39 33 00 00 |........|l%..93..|
|00000530| 00 01 61 b1 07 00 06 1a | 00 00 39 34 00 00 00 01 |..a.....|..94....|
|00000540| 67 cb 07 00 37 1d 00 00 | 39 35 00 00 00 01 9e e8 |g...7...|95......|
|00000550| 07 00 3d 16 00 00 39 36 | 00 00 00 01 db fe 07 00 |..=...96|........|
|00000560| 0b 14 00 00 39 37 00 00 | 00 01 e6 12 08 00 15 1d |....97..|........|
|00000570| 00 00 39 38 00 00 00 01 | fb 2f 08 00 6e 32 00 00 |..98....|./..n2..|
|00000580| 39 39 00 00 00 01 69 62 | 08 00 5a 11 00 00 00 00 |99....ib|..Z.....|
|00000590| 00 00 00 00 c3 73 08 00 | 00 00 00 00 24 55 6e 69 |.....s..|....$Uni|
|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 37 36 30 30 7d |que_ID{Y|RB07600}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 54 65 6d 70 6f 72 61 |..$Title|{Tempora|
|000005c0| 6c 20 4c 6f 62 65 20 45 | 70 69 6c 65 70 73 79 20 |l Lobe E|pilepsy |
|000005d0| 69 6e 20 43 68 69 6c 64 | 68 6f 6f 64 3a 20 20 52 |in Child|hood: R|
|000005e0| 65 61 70 70 72 61 69 73 | 61 6c 20 6f 66 20 45 74 |eapprais|al of Et|
|000005f0| 69 6f 6c 6f 67 79 20 61 | 6e 64 20 4f 75 74 63 6f |iology a|nd Outco|
|00000600| 6d 65 7d 0d 0a 24 41 75 | 74 68 6f 72 7b 0d 0a 48 |me}..$Au|thor{..H|
|00000610| 61 72 62 6f 72 64 2c 20 | 4d 47 0d 0a 4d 61 6e 73 |arbord, |MG..Mans|
|00000620| 6f 6e 2c 20 4a 49 7d 0d | 0a 24 41 66 66 69 6c 69 |on, JI}.|.$Affili|
|00000630| 61 74 69 6f 6e 7b 41 64 | 65 6c 61 69 64 65 20 43 |ation{Ad|elaide C|
|00000640| 68 69 6c 64 72 65 6e 27 | 73 20 48 6f 73 70 2c 20 |hildren'|s Hosp, |
|00000650| 4e 2e 20 41 64 65 6c 61 | 69 64 65 2c 20 41 75 73 |N. Adela|ide, Aus|
|00000660| 74 72 61 6c 69 61 7d 0d | 0a 24 53 75 62 6a 65 63 |tralia}.|.$Subjec|
|00000670| 74 7b 54 65 6d 70 6f 72 | 61 6c 20 6c 6f 62 65 20 |t{Tempor|al lobe |
|00000680| 65 70 69 6c 65 70 73 79 | 2c 20 65 74 69 6f 6c 6f |epilepsy|, etiolo|
|00000690| 67 79 20 61 6e 64 20 6f | 75 74 63 6f 6d 65 3b 0d |gy and o|utcome;.|
|000006a0| 0a 45 70 69 6c 65 70 73 | 79 20 74 65 6d 70 6f 72 |.Epileps|y tempor|
|000006b0| 61 6c 20 6c 6f 62 65 2c | 20 65 74 69 6f 6c 6f 67 |al lobe,| etiolog|
|000006c0| 79 20 61 6e 64 20 6f 75 | 74 63 6f 6d 65 7d 0d 0a |y and ou|tcome}..|
|000006d0| 24 4a 6f 75 72 6e 61 6c | 7b 50 65 64 69 61 74 72 |$Journal|{Pediatr|
|000006e0| 20 4e 65 75 72 6f 6c 7d | 0d 0a 24 56 6f 6c 75 6d | Neurol}|..$Volum|
|000006f0| 65 7b 33 7d 0d 0a 24 50 | 61 67 65 7b 32 36 33 2d |e{3}..$P|age{263-|
|00000700| 32 36 38 7d 0d 0a 24 44 | 61 74 65 7b 53 65 70 74 |268}..$D|ate{Sept|
|00000710| 65 6d 62 65 72 2d 4f 63 | 74 6f 62 65 72 20 31 39 |ember-Oc|tober 19|
|00000720| 38 37 7d 0d 0a 24 59 42 | 56 6f 6c 7b 31 39 38 39 |87}..$YB|Vol{1989|
|00000730| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 50 65 | Year Bo|ok of Pe|
|00000740| 64 69 61 74 72 69 63 73 | 7d 0d 0a 24 43 68 61 70 |diatrics|}..$Chap|
|00000750| 74 65 72 7b 36 2d 36 7d | 0d 0a 24 59 42 45 64 69 |ter{6-6}|..$YBEdi|
|00000760| 74 6f 72 7b 44 72 73 2e | 20 4f 73 6b 69 20 61 6e |tor{Drs.| Oski an|
|00000770| 64 20 53 74 6f 63 6b 6d | 61 6e 7d 0d 0a 24 54 61 |d Stockm|an}..$Ta|
|00000780| 62 6c 65 7b 54 61 62 6c | 65 20 4f 6d 69 74 74 65 |ble{Tabl|e Omitte|
|00000790| 64 7d 0d 0a 24 43 6f 6d | 6d 65 6e 74 61 74 6f 72 |d}..$Com|mentator|
|000007a0| 7b 45 2e 20 56 69 6e 69 | 6e 67 2c 20 4d 2e 44 2e |{E. Vini|ng, M.D.|
|000007b0| 7d 0d 0a 0d 0a 43 6f 70 | 79 72 69 67 68 74 20 28 |}....Cop|yright (|
|000007c0| 63 29 20 59 65 61 72 20 | 42 6f 6f 6b 20 4d 65 64 |c) Year |Book Med|
|000007d0| 69 63 61 6c 20 50 75 62 | 6c 69 73 68 65 72 73 2c |ical Pub|lishers,|
|000007e0| 20 49 6e 63 2e 2c 20 31 | 39 38 39 0d 0a 0d 0a 31 | Inc., 1|989....1|
|000007f0| 39 38 39 20 59 65 61 72 | 20 42 6f 6f 6b 20 6f 66 |989 Year| Book of|
|00000800| 20 50 65 64 69 61 74 72 | 69 63 73 20 28 52 29 0d | Pediatr|ics (R).|
|00000810| 0a 0d 0a 43 68 61 70 74 | 65 72 20 36 2d 2d 4e 65 |...Chapt|er 6--Ne|
|00000820| 75 72 6f 6c 6f 67 79 20 | 61 6e 64 20 50 73 79 63 |urology |and Psyc|
|00000830| 68 69 61 74 72 79 0d 0a | 0d 0a 2d 2d 2d 2d 2d 2d |hiatry..|..------|
|00000840| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000850| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000860| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000870| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000880| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 54 65 6d 70 |--------|--..Temp|
|00000890| 6f 72 61 6c 20 4c 6f 62 | 65 20 45 70 69 6c 65 70 |oral Lob|e Epilep|
|000008a0| 73 79 20 69 6e 20 43 68 | 69 6c 64 68 6f 6f 64 3a |sy in Ch|ildhood:|
|000008b0| 20 20 52 65 61 70 70 72 | 61 69 73 61 6c 20 6f 66 | Reappr|aisal of|
|000008c0| 20 45 74 69 6f 6c 6f 67 | 79 20 61 6e 64 20 4f 75 | Etiolog|y and Ou|
|000008d0| 74 63 6f 6d 65 0d 0a 0d | 0a 48 61 72 62 6f 72 64 |tcome...|.Harbord|
|000008e0| 20 4d 47 2c 20 4d 61 6e | 73 6f 6e 20 4a 49 0d 0a | MG, Man|son JI..|
|000008f0| 28 41 64 65 6c 61 69 64 | 65 20 43 68 69 6c 64 72 |(Adelaid|e Childr|
|00000900| 65 6e 27 73 20 48 6f 73 | 70 2c 20 4e 2e 20 41 64 |en's Hos|p, N. Ad|
|00000910| 65 6c 61 69 64 65 2c 20 | 41 75 73 74 72 61 6c 69 |elaide, |Australi|
|00000920| 61 29 0d 0a 50 65 64 69 | 61 74 72 20 4e 65 75 72 |a)..Pedi|atr Neur|
|00000930| 6f 6c 20 33 3a 32 36 33 | 2d 32 36 38 2c 20 53 65 |ol 3:263|-268, Se|
|00000940| 70 74 65 6d 62 65 72 2d | 4f 63 74 6f 62 65 72 20 |ptember-|October |
|00000950| 31 39 0d 0a 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |19..----|--------|
|00000960| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000970| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000980| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000990| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000009a0| 2d 2d 2d 2d 0d 0a 0d 0a | 41 62 73 74 72 61 63 74 |----....|Abstract|
|000009b0| 0d 0a 0d 0a 20 20 20 20 | 20 54 65 6d 70 6f 72 61 |.... | Tempora|
|000009c0| 6c 20 6c 6f 62 65 20 65 | 70 69 6c 65 70 73 79 20 |l lobe e|pilepsy |
|000009d0| 28 54 4c 45 29 20 69 73 | 20 61 20 63 6f 6d 6d 6f |(TLE) is| a commo|
|000009e0| 6e 20 74 79 70 65 20 6f | 66 20 63 68 69 6c 64 68 |n type o|f childh|
|000009f0| 6f 6f 64 20 65 70 69 6c | 65 70 73 79 2e 20 20 54 |ood epil|epsy. T|
|00000a00| 68 65 0d 0a 65 74 69 6f | 6c 6f 67 79 20 61 6e 64 |he..etio|logy and|
|00000a10| 20 6f 75 74 63 6f 6d 65 | 20 69 6e 20 36 33 20 72 | outcome| in 63 r|
|00000a20| 65 74 72 6f 73 70 65 63 | 74 69 76 65 6c 79 20 61 |etrospec|tively a|
|00000a30| 6e 61 6c 79 7a 65 64 20 | 63 68 69 6c 64 72 65 6e |nalyzed |children|
|00000a40| 2c 20 61 67 65 64 20 32 | 2d 31 35 20 79 65 61 72 |, aged 2|-15 year|
|00000a50| 73 2c 0d 0a 77 69 74 68 | 20 54 4c 45 20 77 65 72 |s,..with| TLE wer|
|00000a60| 65 20 65 78 61 6d 69 6e | 65 64 2e 0d 0a 20 20 20 |e examin|ed... |
|00000a70| 20 20 4d 6f 72 65 20 74 | 68 61 6e 20 74 77 6f 20 | More t|han two |
|00000a80| 74 68 69 72 64 73 20 6f | 66 20 74 68 65 73 65 20 |thirds o|f these |
|00000a90| 63 68 69 6c 64 72 65 6e | 20 68 61 64 20 73 65 69 |children| had sei|
|00000aa0| 7a 75 72 65 73 20 61 74 | 20 6c 65 61 73 74 20 6f |zures at| least o|
|00000ab0| 6e 63 65 20 61 20 77 65 | 65 6b 0d 0a 28 54 61 62 |nce a we|ek..(Tab|
|00000ac0| 6c 65 20 31 29 2e 20 20 | 47 65 6e 65 72 61 6c 69 |le 1). |Generali|
|00000ad0| 7a 65 64 20 74 6f 6e 69 | 63 2d 63 6c 6f 6e 69 63 |zed toni|c-clonic|
|00000ae0| 20 73 65 69 7a 75 72 65 | 73 20 77 65 72 65 20 72 | seizure|s were r|
|00000af0| 65 70 6f 72 74 65 64 20 | 69 6e 20 31 30 20 70 61 |eported |in 10 pa|
|00000b00| 74 69 65 6e 74 73 2e 0d | 0a 53 65 69 7a 75 72 65 |tients..|.Seizure|
|00000b10| 73 20 77 65 72 65 20 66 | 72 65 71 75 65 6e 74 6c |s were f|requentl|
|00000b20| 79 20 70 72 65 63 65 64 | 65 64 20 62 79 20 61 75 |y preced|ed by au|
|00000b30| 74 6f 6e 6f 6d 69 63 20 | 6d 61 6e 69 66 65 73 74 |tonomic |manifest|
|00000b40| 61 74 69 6f 6e 73 20 61 | 6e 64 20 76 6f 63 61 6c |ations a|nd vocal|
|00000b50| 69 7a 61 74 69 6f 6e 0d | 0a 28 54 61 62 6c 65 20 |ization.|.(Table |
|00000b60| 32 29 2e 20 20 4e 6f 72 | 6d 61 6c 20 69 6e 74 65 |2). Nor|mal inte|
|00000b70| 6c 6c 69 67 65 6e 63 65 | 20 77 61 73 20 66 6f 75 |lligence| was fou|
|00000b80| 6e 64 20 69 6e 20 37 31 | 25 20 61 6e 64 20 6c 6f |nd in 71|% and lo|
|00000b90| 77 20 69 6e 74 65 6c 6c | 69 67 65 6e 63 65 20 69 |w intell|igence i|
|00000ba0| 6e 20 32 39 25 2e 0d 0a | 45 6d 6f 74 69 6f 6e 61 |n 29%...|Emotiona|
|00000bb0| 6c 20 6f 72 20 62 65 68 | 61 76 69 6f 72 61 6c 20 |l or beh|avioral |
|00000bc0| 70 72 6f 62 6c 65 6d 73 | 20 77 65 72 65 20 70 72 |problems| were pr|
|00000bd0| 65 73 65 6e 74 20 69 6e | 20 32 34 25 2e 20 54 68 |esent in| 24%. Th|
|00000be0| 69 73 20 77 61 73 20 73 | 69 67 6e 69 66 69 63 61 |is was s|ignifica|
|00000bf0| 6e 74 6c 79 0d 0a 6d 6f | 72 65 20 63 6f 6d 6d 6f |ntly..mo|re commo|
|00000c00| 6e 20 69 6e 20 74 68 6f | 73 65 20 6f 66 20 6c 6f |n in tho|se of lo|
|00000c10| 77 20 69 6e 74 65 6c 6c | 69 67 65 6e 63 65 2e 20 |w intell|igence. |
|00000c20| 20 54 68 65 20 45 45 47 | 20 66 6f 63 75 73 20 77 | The EEG| focus w|
|00000c30| 61 73 20 72 69 67 68 74 | 2d 73 69 64 65 64 20 69 |as right|-sided i|
|00000c40| 6e 20 33 33 0d 0a 70 61 | 74 69 65 6e 74 73 2c 20 |n 33..pa|tients, |
|00000c50| 6c 65 66 74 2d 73 69 64 | 65 64 20 69 6e 20 32 35 |left-sid|ed in 25|
|00000c60| 2c 20 61 6e 64 20 62 69 | 6c 61 74 65 72 61 6c 20 |, and bi|lateral |
|00000c70| 69 6e 20 35 2e 20 20 54 | 75 6d 6f 72 73 20 77 65 |in 5. T|umors we|
|00000c80| 72 65 20 64 65 74 65 63 | 74 65 64 20 69 6e 20 36 |re detec|ted in 6|
|00000c90| 0d 0a 70 61 74 69 65 6e | 74 73 2c 20 61 6e 64 20 |..patien|ts, and |
|00000ca0| 66 6f 63 61 6c 20 61 74 | 72 6f 70 68 79 20 77 61 |focal at|rophy wa|
|00000cb0| 73 20 64 65 74 65 63 74 | 65 64 20 69 6e 20 31 32 |s detect|ed in 12|
|00000cc0| 20 70 61 74 69 65 6e 74 | 73 2e 20 20 54 68 65 72 | patient|s. Ther|
|00000cd0| 65 20 77 61 73 20 61 0d | 0a 70 72 65 64 69 73 70 |e was a.|.predisp|
|00000ce0| 6f 73 69 6e 67 20 66 61 | 63 74 6f 72 20 69 6e 20 |osing fa|ctor in |
|00000cf0| 34 35 20 70 61 74 69 65 | 6e 74 73 28 54 61 62 6c |45 patie|nts(Tabl|
|00000d00| 65 20 33 29 2e 20 20 54 | 68 65 72 65 20 77 61 73 |e 3). T|here was|
|00000d10| 20 61 20 74 65 6e 64 65 | 6e 63 79 20 66 6f 72 20 | a tende|ncy for |
|00000d20| 74 68 65 0d 0a 73 65 69 | 7a 75 72 65 73 20 74 6f |the..sei|zures to|
|00000d30| 20 72 65 64 75 63 65 20 | 69 6e 20 66 72 65 71 75 | reduce |in frequ|
|00000d40| 65 6e 63 79 20 6f 76 65 | 72 20 74 69 6d 65 2c 20 |ency ove|r time, |
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|00001f60| 2d 39 34 36 7d 0d 0a 24 | 44 61 74 65 7b 41 70 72 |-946}..$|Date{Apr|
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|00001ff0| 6d 6d 65 6e 74 61 74 6f | 72 7b 46 2e 41 2e 20 4f |mmentato|r{F.A. O|
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|00002010| 70 79 72 69 67 68 74 20 | 28 63 29 20 59 65 61 72 |pyright |(c) Year|
|00002020| 20 42 6f 6f 6b 20 4d 65 | 64 69 63 61 6c 20 50 75 | Book Me|dical Pu|
|00002030| 62 6c 69 73 68 65 72 73 | 2c 20 49 6e 63 2e 2c 20 |blishers|, Inc., |
|00002040| 31 39 38 39 0d 0a 0d 0a | 31 39 38 39 20 59 65 61 |1989....|1989 Yea|
|00002050| 72 20 42 6f 6f 6b 20 6f | 66 20 50 65 64 69 61 74 |r Book o|f Pediat|
|00002060| 72 69 63 73 20 28 52 29 | 0d 0a 0d 0a 43 68 61 70 |rics (R)|....Chap|
|00002070| 74 65 72 20 36 2d 2d 4e | 65 75 72 6f 6c 6f 67 79 |ter 6--N|eurology|
|00002080| 20 61 6e 64 20 50 73 79 | 63 68 69 61 74 72 79 0d | and Psy|chiatry.|
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|000020a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000020b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000020c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000020d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000020e0| 2d 2d 2d 0d 0a 57 69 74 | 68 64 72 61 77 61 6c 20 |---..Wit|hdrawal |
|000020f0| 6f 66 20 41 6e 74 69 63 | 6f 6e 76 75 6c 73 61 6e |of Antic|onvulsan|
|00002100| 74 20 44 72 75 67 73 20 | 69 6e 20 50 61 74 69 65 |t Drugs |in Patie|
|00002110| 6e 74 73 20 46 72 65 65 | 20 6f 66 20 53 65 69 7a |nts Free| of Seiz|
|00002120| 75 72 65 73 20 66 6f 72 | 20 54 77 6f 20 59 65 61 |ures for| Two Yea|
|00002130| 72 73 3a 0d 0a 41 20 50 | 72 6f 73 70 65 63 74 69 |rs:..A P|rospecti|
|00002140| 76 65 20 53 74 75 64 79 | 0d 0a 0d 0a 43 61 6c 6c |ve Study|....Call|
|00002150| 61 67 68 61 6e 20 4e 2c | 20 47 61 72 72 65 74 74 |aghan N,| Garrett|
|00002160| 20 41 2c 20 47 6f 67 67 | 69 6e 20 54 0d 0a 28 43 | A, Gogg|in T..(C|
|00002170| 6f 72 6b 20 52 65 67 69 | 6f 6e 61 6c 20 48 6f 73 |ork Regi|onal Hos|
|00002180| 70 2c 20 55 6e 69 76 20 | 43 6f 6c 6c 65 67 65 2c |p, Univ |College,|
|00002190| 20 43 6f 72 6b 2c 20 49 | 72 65 6c 61 6e 64 3b 20 | Cork, I|reland; |
|000021a0| 50 61 72 6b 65 2d 44 61 | 76 69 73 2c 20 4d 63 44 |Parke-Da|vis, McD|
|000021b0| 6f 6e 6e 65 6c 6c 2d 44 | 6f 75 67 6c 61 73 0d 0a |onnell-D|ouglas..|
|000021c0| 53 79 73 74 65 6d 73 2c | 20 4c 6f 6e 64 6f 6e 29 |Systems,| London)|
|000021d0| 0d 0a 4e 20 45 6e 67 6c | 20 4a 20 4d 65 64 20 33 |..N Engl| J Med 3|
|000021e0| 31 38 3a 39 34 32 2d 39 | 34 36 2c 20 41 70 72 69 |18:942-9|46, Apri|
|000021f0| 6c 20 31 34 2c 20 31 39 | 38 38 0d 0a 2d 2d 2d 2d |l 14, 19|88..----|
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|00002210| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002220| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002230| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002240| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 0d 0a |--------|----....|
|00002250| 41 62 73 74 72 61 63 74 | 0d 0a 0d 0a 20 20 20 20 |Abstract|.... |
|00002260| 20 42 65 63 61 75 73 65 | 20 6f 66 20 74 68 65 69 | Because| of thei|
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|00002280| 63 20 65 66 66 65 63 74 | 73 2c 20 70 72 6f 6c 6f |c effect|s, prolo|
|00002290| 6e 67 65 64 20 74 72 65 | 61 74 6d 65 6e 74 20 77 |nged tre|atment w|
|000022a0| 69 74 68 0d 0a 61 6e 74 | 69 63 6f 6e 76 75 6c 73 |ith..ant|iconvuls|
|000022b0| 61 6e 74 20 64 72 75 67 | 73 20 73 68 6f 75 6c 64 |ant drug|s should|
|000022c0| 20 62 65 20 61 76 6f 69 | 64 65 64 2c 20 70 61 72 | be avoi|ded, par|
|000022d0| 74 69 63 75 6c 61 72 6c | 79 20 69 66 20 73 61 74 |ticularl|y if sat|
|000022e0| 69 73 66 61 63 74 6f 72 | 79 20 63 6f 6e 74 72 6f |isfactor|y contro|
|000022f0| 6c 20 6f 66 0d 0a 73 65 | 69 7a 75 72 65 73 20 68 |l of..se|izures h|
|00002300| 61 73 20 62 65 65 6e 20 | 61 63 68 69 65 76 65 64 |as been |achieved|
|00002310| 2e 20 20 49 6e 20 61 20 | 70 72 6f 73 70 65 63 74 |. In a |prospect|
|00002320| 69 76 65 20 73 74 75 64 | 79 2c 20 61 6e 74 69 63 |ive stud|y, antic|
|00002330| 6f 6e 76 75 6c 73 61 6e | 74 20 64 72 75 67 20 74 |onvulsan|t drug t|
|00002340| 68 65 72 61 70 79 0d 0a | 77 61 73 20 64 69 73 63 |herapy..|was disc|
|00002350| 6f 6e 74 69 6e 75 65 64 | 20 69 6e 20 39 32 20 70 |ontinued| in 92 p|
|00002360| 61 74 69 65 6e 74 73 20 | 77 68 6f 20 68 61 64 20 |atients |who had |
|00002370| 62 65 65 6e 20 66 72 65 | 65 20 6f 66 20 73 65 69 |been fre|e of sei|
|00002380| 7a 75 72 65 73 20 64 75 | 72 69 6e 67 20 32 20 79 |zures du|ring 2 y|
|00002390| 65 61 72 73 20 6f 66 0d | 0a 74 72 65 61 74 6d 65 |ears of.|.treatme|
|000023a0| 6e 74 20 77 69 74 68 20 | 61 20 73 69 6e 67 6c 65 |nt with |a single|
|000023b0| 20 64 72 75 67 20 74 6f | 20 64 65 74 65 72 6d 69 | drug to| determi|
|000023c0| 6e 65 20 74 68 65 20 66 | 61 63 74 6f 72 73 20 61 |ne the f|actors a|
|000023d0| 73 73 6f 63 69 61 74 65 | 64 20 77 69 74 68 20 72 |ssociate|d with r|
|000023e0| 65 6c 61 70 73 65 0d 0a | 61 66 74 65 72 20 77 69 |elapse..|after wi|
|000023f0| 74 68 64 72 61 77 61 6c | 20 6f 66 20 74 68 65 73 |thdrawal| of thes|
|00002400| 65 20 61 67 65 6e 74 73 | 2e 20 20 41 6c 6c 20 70 |e agents|. All p|
|00002410| 61 74 69 65 6e 74 73 20 | 68 61 64 20 65 70 69 6c |atients |had epil|
|00002420| 65 70 73 79 20 74 68 61 | 74 20 68 61 64 20 70 72 |epsy tha|t had pr|
|00002430| 65 76 69 6f 75 73 6c 79 | 0d 0a 62 65 65 6e 20 75 |eviously|..been u|
|00002440| 6e 74 72 65 61 74 65 64 | 20 61 6e 64 20 61 74 20 |ntreated| and at |
|00002450| 64 69 61 67 6e 6f 73 69 | 73 20 68 61 64 20 62 65 |diagnosi|s had be|
|00002460| 65 6e 20 72 61 6e 64 6f | 6d 6c 79 20 61 73 73 69 |en rando|mly assi|
|00002470| 67 6e 65 64 20 74 6f 20 | 72 65 63 65 69 76 65 0d |gned to |receive.|
|00002480| 0a 63 61 72 62 61 6d 61 | 7a 65 70 69 6e 65 2c 20 |.carbama|zepine, |
|00002490| 70 68 65 6e 79 74 6f 69 | 6e 2c 20 6f 72 20 73 6f |phenytoi|n, or so|
|000024a0| 64 69 75 6d 20 76 61 6c | 70 72 6f 61 74 65 20 61 |dium val|proate a|
|000024b0| 73 20 73 69 6e 67 6c 65 | 2d 64 72 75 67 20 74 72 |s single|-drug tr|
|000024c0| 65 61 74 6d 65 6e 74 2e | 0d 0a 20 20 20 20 20 54 |eatment.|.. T|
|000024d0| 68 69 72 74 79 2d 6f 6e | 65 20 70 61 74 69 65 6e |hirty-on|e patien|
|000024e0| 74 73 20 72 65 6c 61 70 | 73 65 64 20 61 6e 64 20 |ts relap|sed and |
|000024f0| 36 31 20 72 65 6d 61 69 | 6e 65 64 20 66 72 65 65 |61 remai|ned free|
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|00002520| 20 66 6f 6c 6c 6f 77 2d | 75 70 20 69 6e 20 70 61 | follow-|up in pa|
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|00002540| 6e 65 64 20 73 65 69 7a | 75 72 65 20 66 72 65 65 |ned seiz|ure free|
|00002550| 20 77 61 73 20 33 35 20 | 6d 6f 6e 74 68 73 0d 0a | was 35 |months..|
|00002560| 28 72 61 6e 67 65 2c 20 | 36 2d 36 32 20 6d 6f 6e |(range, |6-62 mon|
|00002570| 74 68 73 29 2e 20 20 54 | 68 65 20 72 65 6c 61 70 |ths). T|he relap|
|00002580| 73 65 20 72 61 74 65 20 | 64 69 64 20 6e 6f 74 20 |se rate |did not |
|00002590| 64 69 66 66 65 72 20 73 | 69 67 6e 69 66 69 63 61 |differ s|ignifica|
|000025a0| 6e 74 6c 79 20 62 65 74 | 77 65 65 6e 0d 0a 63 68 |ntly bet|ween..ch|
|000025b0| 69 6c 64 72 65 6e 20 28 | 33 31 25 29 20 61 6e 64 |ildren (|31%) and|
|000025c0| 20 61 64 75 6c 74 73 20 | 28 33 35 25 29 2e 20 20 | adults |(35%). |
|000025d0| 52 65 6c 61 70 73 65 20 | 77 61 73 20 73 69 67 6e |Relapse |was sign|
|000025e0| 69 66 69 63 61 6e 74 6c | 79 20 61 73 73 6f 63 69 |ificantl|y associ|
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|00002600| 67 65 72 20 64 75 72 61 | 74 69 6f 6e 20 6f 66 20 |ger dura|tion of |
|00002610| 74 72 65 61 74 6d 65 6e | 74 2c 20 67 65 6e 65 72 |treatmen|t, gener|
|00002620| 61 6c 69 7a 65 64 20 6f | 72 20 73 69 6d 70 6c 65 |alized o|r simple|
|00002630| 20 70 61 72 74 69 61 6c | 20 73 65 69 7a 75 72 65 | partial| seizure|
|00002640| 73 20 77 69 74 68 0d 0a | 73 65 63 6f 6e 64 61 72 |s with..|secondar|
|00002650| 79 20 67 65 6e 65 72 61 | 6c 69 7a 61 74 69 6f 6e |y genera|lization|
|00002660| 2c 20 75 73 65 20 6f 66 | 20 6d 6f 72 65 20 74 68 |, use of| more th|
|00002670| 61 6e 20 31 20 64 72 75 | 67 20 61 73 20 73 69 6e |an 1 dru|g as sin|
|00002680| 67 6c 65 2d 64 72 75 67 | 20 74 68 65 72 61 70 79 |gle-drug| therapy|
|00002690| 20 74 6f 0d 0a 6f 62 74 | 61 69 6e 20 73 65 69 7a | to..obt|ain seiz|
|000026a0| 75 72 65 20 63 6f 6e 74 | 72 6f 6c 2c 20 6d 6f 72 |ure cont|rol, mor|
|000026b0| 65 20 73 65 69 7a 75 72 | 65 73 20 62 65 66 6f 72 |e seizur|es befor|
|000026c0| 65 20 61 63 68 69 65 76 | 65 6d 65 6e 74 20 6f 66 |e achiev|ement of|
|000026d0| 20 63 6f 6e 74 72 6f 6c | 2c 20 61 6e 64 20 61 6e | control|, and an|
|000026e0| 20 45 45 47 0d 0a 63 6c | 61 73 73 69 66 69 63 61 | EEG..cl|assifica|
|000026f0| 74 69 6f 6e 20 6f 66 20 | 33 20 6f 72 20 34 20 28 |tion of |3 or 4 (|
|00002700| 54 61 62 6c 65 20 31 29 | 2e 20 20 50 61 74 69 65 |Table 1)|. Patie|
|00002710| 6e 74 73 20 77 69 74 68 | 20 63 6f 6d 70 6c 65 78 |nts with| complex|
|00002720| 20 6f 72 20 73 69 6d 70 | 6c 65 20 70 61 72 74 69 | or simp|le parti|
|00002730| 61 6c 0d 0a 73 65 69 7a | 75 72 65 73 20 77 69 74 |al..seiz|ures wit|
|00002740| 68 20 73 65 63 6f 6e 64 | 61 72 79 20 67 65 6e 65 |h second|ary gene|
|00002750| 72 61 6c 69 7a 61 74 69 | 6f 6e 2c 20 74 68 6f 73 |ralizati|on, thos|
|00002760| 65 20 77 69 74 68 20 63 | 6c 61 73 73 20 34 20 65 |e with c|lass 4 e|
|00002770| 6e 63 65 70 68 61 6c 6f | 67 72 61 6d 73 2c 20 61 |ncephalo|grams, a|
|00002780| 6e 64 0d 0a 74 68 6f 73 | 65 20 69 6e 20 77 68 6f |nd..thos|e in who|
|00002790| 6d 20 73 6f 64 69 75 6d | 20 76 61 6c 70 72 6f 61 |m sodium| valproa|
|000027a0| 74 65 20 77 61 73 20 64 | 69 73 63 6f 6e 74 69 6e |te was d|iscontin|
|000027b0| 75 65 64 20 68 61 64 20 | 74 68 65 20 77 6f 72 73 |ued had |the wors|
|000027c0| 74 20 70 72 6f 67 6e 6f | 73 69 73 20 28 54 61 62 |t progno|sis (Tab|
|000027d0| 6c 65 0d 0a 32 29 2e 0d | 0a 20 20 20 20 20 54 68 |le..2)..|. Th|
|000027e0| 65 20 72 65 6c 61 70 73 | 65 20 72 61 74 65 20 77 |e relaps|e rate w|
|000027f0| 61 73 20 35 2e 39 25 20 | 70 65 72 20 6d 6f 6e 74 |as 5.9% |per mont|
|00002800| 68 20 66 6f 72 20 74 68 | 65 20 66 69 72 73 74 20 |h for th|e first |
|00002810| 33 20 6d 6f 6e 74 68 73 | 20 61 6e 64 20 64 65 63 |3 months| and dec|
|00002820| 6c 69 6e 65 64 20 74 6f | 0d 0a 30 2e 35 25 20 70 |lined to|..0.5% p|
|00002830| 65 72 20 6d 6f 6e 74 68 | 20 69 6e 20 74 68 65 20 |er month| in the |
|00002840| 69 6e 74 65 72 76 61 6c | 20 62 65 74 77 65 65 6e |interval| between|
|00002850| 20 36 20 61 6e 64 20 39 | 20 6d 6f 6e 74 68 73 20 | 6 and 9| months |
|00002860| 61 66 74 65 72 20 77 69 | 74 68 64 72 61 77 61 6c |after wi|thdrawal|
|00002870| 20 28 46 69 67 0d 0a 36 | 2d 31 29 2e 0d 0a 20 20 | (Fig..6|-1)... |
|00002880| 20 20 20 57 69 74 68 64 | 72 61 77 61 6c 20 6f 66 | Withd|rawal of|
|00002890| 20 61 6e 74 69 63 6f 6e | 76 75 6c 73 61 6e 74 20 | anticon|vulsant |
|000028a0| 64 72 75 67 73 20 73 68 | 6f 75 6c 64 20 62 65 20 |drugs sh|ould be |
|000028b0| 63 6f 6e 73 69 64 65 72 | 65 64 20 69 6e 20 70 61 |consider|ed in pa|
|000028c0| 74 69 65 6e 74 73 20 77 | 68 6f 20 61 72 65 0d 0a |tients w|ho are..|
|000028d0| 66 72 65 65 20 6f 66 20 | 73 65 69 7a 75 72 65 73 |free of |seizures|
|000028e0| 20 66 6f 72 20 32 20 79 | 65 61 72 73 2e 0d 0a 0d | for 2 y|ears....|
|000028f0| 0a 50 6f 73 74 2d 43 6f | 6d 6d 65 6e 74 0d 0a 0d |.Post-Co|mment...|
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|00002eb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002ec0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00003030| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003040| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003050| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 0d 0a 0d 0a 41 |--------|---....A|
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|000049b0| 6d 6d 65 6e 74 61 74 6f | 72 7b 46 2e 41 2e 20 4f |mmentato|r{F.A. O|
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|00004a50| 0a 0d 0a 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |...-----|--------|
|00004a60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004a70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004a80| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004a90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004aa0| 2d 2d 2d 0d 0a 4d 75 6c | 74 69 70 6c 65 20 53 63 |---..Mul|tiple Sc|
|00004ab0| 6c 65 72 6f 73 69 73 20 | 69 6e 20 43 68 69 6c 64 |lerosis |in Child|
|00004ac0| 68 6f 6f 64 3a 20 20 43 | 6c 69 6e 69 63 61 6c 20 |hood: C|linical |
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|00004ae0| 61 74 69 65 6e 74 73 0d | 0a 0d 0a 44 75 71 75 65 |atients.|...Duque|
|00004af0| 74 74 65 20 50 2c 20 4d | 75 72 72 61 79 20 54 4a |tte P, M|urray TJ|
|00004b00| 2c 20 50 6c 65 69 6e 65 | 73 20 4a 2c 20 45 62 65 |, Pleine|s J, Ebe|
|00004b10| 72 73 20 47 43 2c 20 53 | 61 64 6f 76 6e 69 63 6b |rs GC, S|adovnick|
|00004b20| 20 44 2c 20 57 65 6c 64 | 6f 6e 20 50 2c 20 57 61 | D, Weld|on P, Wa|
|00004b30| 72 72 65 6e 20 53 2c 0d | 0a 50 61 74 79 20 44 57 |rren S,.|.Paty DW|
|00004b40| 2c 20 55 70 74 6f 6e 20 | 41 2c 20 48 61 64 65 72 |, Upton |A, Hader|
|00004b50| 20 57 2c 20 4e 65 6c 73 | 6f 6e 20 52 2c 20 41 75 | W, Nels|on R, Au|
|00004b60| 74 79 20 41 2c 20 4e 65 | 75 66 65 6c 64 20 42 2c |ty A, Ne|ufeld B,|
|00004b70| 20 4d 65 6c 74 7a 65 72 | 20 43 0d 0a 28 4d 6f 6e | Meltzer| C..(Mon|
|00004b80| 74 72 65 61 6c 2c 20 51 | 75 65 62 65 63 2c 20 61 |treal, Q|uebec, a|
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|00004bb0| 69 61 74 72 20 31 31 31 | 3a 33 35 39 2d 33 36 33 |iatr 111|:359-363|
|00004bc0| 2c 20 53 65 70 74 65 6d | 62 65 72 20 31 39 38 37 |, Septem|ber 1987|
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|00004c00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004c10| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00004c60| 28 4d 53 29 20 75 73 75 | 61 6c 6c 79 20 6f 63 63 |(MS) usu|ally occ|
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|00004c80| 75 6c 74 68 6f 6f 64 2c | 20 74 68 65 20 61 67 65 |ulthood,| the age|
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|000053a0| 2e 20 4f 66 20 31 31 38 | 20 70 61 74 69 65 6e 74 |. Of 118| patient|
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|00005400| 65 6c 73 20 69 6e 20 63 | 65 72 65 62 72 6f 73 70 |els in c|erebrosp|
|00005410| 69 6e 61 6c 20 66 6c 75 | 69 64 20 28 43 53 46 29 |inal flu|id (CSF)|
|00005420| 3b 20 74 68 65 0d 0a 72 | 65 6d 61 69 6e 64 65 72 |; the..r|emainder|
|00005430| 20 68 61 64 20 6e 6f 72 | 6d 61 6c 20 6c 65 76 65 | had nor|mal leve|
|00005440| 6c 73 2e 0d 0a 20 20 20 | 20 20 49 6e 20 74 68 69 |ls... | In thi|
|00005450| 73 20 73 74 75 64 79 2c | 20 6f 6e 73 65 74 20 6f |s study,| onset o|
|00005460| 66 20 4d 53 20 69 6e 20 | 63 68 69 6c 64 68 6f 6f |f MS in |childhoo|
|00005470| 64 20 61 70 70 65 61 72 | 65 64 20 74 6f 20 62 65 |d appear|ed to be|
|00005480| 20 33 20 74 69 6d 65 73 | 20 6d 6f 72 65 20 63 6f | 3 times| more co|
|00005490| 6d 6d 6f 6e 0d 0a 61 6d | 6f 6e 67 20 67 69 72 6c |mmon..am|ong girl|
|000054a0| 73 20 74 68 61 6e 20 62 | 6f 79 73 2e 20 20 43 68 |s than b|oys. Ch|
|000054b0| 69 6c 64 68 6f 6f 64 20 | 6f 6e 73 65 74 20 4d 53 |ildhood |onset MS|
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|000054d0| 20 61 20 72 65 6c 61 70 | 73 69 6e 67 2d 72 65 6d | a relap|sing-rem|
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|00005510| 66 66 65 72 65 6e 74 20 | 73 74 72 75 63 74 75 72 |fferent |structur|
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|00005570| 6f 6f 64 20 6f 6e 73 65 | 74 20 4d 53 20 77 61 73 |ood onse|t MS was|
|00005580| 20 74 65 6e 64 65 64 0d | 0a 74 6f 20 62 65 20 73 | tended.|.to be s|
|00005590| 6c 6f 77 2e 0d 0a 0d 0a | 50 6f 73 74 2d 43 6f 6d |low.....|Post-Com|
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|00005750| 6f 64 20 66 6f 72 20 64 | 65 74 65 63 74 69 6e 67 |od for d|etecting|
|00005760| 20 4d 53 2e 20 54 68 69 | 73 20 69 73 20 70 61 72 | MS. Thi|s is par|
|00005770| 74 69 63 75 6c 61 72 6c | 79 20 74 72 75 65 20 66 |ticularl|y true f|
|00005780| 6f 72 0d 0a 6c 65 73 69 | 6f 6e 73 20 69 6e 76 6f |or..lesi|ons invo|
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|000057c0| 6c 69 7a 65 64 20 62 79 | 20 63 6f 6d 70 75 74 65 |lized by| compute|
|000057d0| 64 0d 0a 74 6f 6d 6f 67 | 72 61 70 68 79 2e 20 20 |d..tomog|raphy. |
|000057e0| 54 68 69 6e 6b 20 4d 53 | 2c 20 64 65 73 70 69 74 |Think MS|, despit|
|000057f0| 65 20 69 74 73 20 72 61 | 72 69 74 79 2c 20 77 68 |e its ra|rity, wh|
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|00005810| 74 68 20 61 20 63 68 69 | 6c 64 20 77 68 6f 0d 0a |th a chi|ld who..|
|00005820| 64 65 76 65 6c 6f 70 73 | 20 73 79 6d 70 74 6f 6d |develops| symptom|
|00005830| 73 20 6f 66 20 6e 65 75 | 72 6f 6c 6f 67 69 63 20 |s of neu|rologic |
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|00005860| 65 63 74 69 76 65 0d 0a | 63 6f 6e 66 69 72 6d 61 |ective..|confirma|
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|00005880| 72 20 6d 6f 72 65 20 74 | 68 61 6e 20 32 34 20 68 |r more t|han 24 h|
|00005890| 6f 75 72 73 2e 2d 2d 46 | 2e 41 2e 20 4f 73 6b 69 |ours.--F|.A. Oski|
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|00005910| 41 75 74 68 6f 72 7b 0d | 0a 44 65 53 69 6c 76 61 |Author{.|.DeSilva|
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|00005950| 6c 69 61 74 69 6f 6e 7b | 4a 6f 68 6e 73 20 48 6f |liation{|Johns Ho|
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|000059c0| 6f 70 68 79 2c 20 70 72 | 65 64 6e 69 73 6f 6e 65 |ophy, pr|ednisone|
|000059d0| 20 69 6e 3b 0d 0a 44 79 | 73 74 72 6f 70 68 79 20 | in;..Dy|strophy |
|000059e0| 44 75 63 68 65 6e 6e 65 | 20 6d 75 73 63 75 6c 61 |Duchenne| muscula|
|000059f0| 72 2c 20 70 72 65 64 6e | 69 73 6f 6e 65 20 69 6e |r, predn|isone in|
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|00005a20| 70 72 65 64 6e 69 73 6f | 6e 65 20 69 6e 7d 0d 0a |predniso|ne in}..|
|00005a30| 24 4a 6f 75 72 6e 61 6c | 7b 41 72 63 68 20 4e 65 |$Journal|{Arch Ne|
|00005a40| 75 72 6f 6c 7d 0d 0a 24 | 56 6f 6c 75 6d 65 7b 34 |urol}..$|Volume{4|
|00005a50| 34 7d 0d 0a 24 50 61 67 | 65 7b 38 31 38 2d 38 32 |4}..$Pag|e{818-82|
|00005a60| 32 7d 0d 0a 24 44 61 74 | 65 7b 41 75 67 75 73 74 |2}..$Dat|e{August|
|00005a70| 20 31 39 38 37 7d 0d 0a | 24 59 42 56 6f 6c 7b 31 | 1987}..|$YBVol{1|
|00005a80| 39 38 39 20 59 65 61 72 | 20 42 6f 6f 6b 20 6f 66 |989 Year| Book of|
|00005a90| 20 50 65 64 69 61 74 72 | 69 63 73 7d 0d 0a 24 43 | Pediatr|ics}..$C|
|00005aa0| 68 61 70 74 65 72 7b 36 | 2d 31 30 7d 0d 0a 24 59 |hapter{6|-10}..$Y|
|00005ab0| 42 45 64 69 74 6f 72 7b | 44 72 73 2e 20 4f 73 6b |BEditor{|Drs. Osk|
|00005ac0| 69 20 61 6e 64 20 53 74 | 6f 63 6b 6d 61 6e 7d 0d |i and St|ockman}.|
|00005ad0| 0a 24 54 61 62 6c 65 7b | 54 61 62 6c 65 20 4f 6d |.$Table{|Table Om|
|00005ae0| 69 74 74 65 64 7d 0d 0a | 24 43 6f 6d 6d 65 6e 74 |itted}..|$Comment|
|00005af0| 61 74 6f 72 7b 46 2e 41 | 2e 20 4f 73 6b 69 2c 20 |ator{F.A|. Oski, |
|00005b00| 4d 2e 44 2e 7d 0d 0a 0d | 0a 43 6f 70 79 72 69 67 |M.D.}...|.Copyrig|
|00005b10| 68 74 20 28 63 29 20 59 | 65 61 72 20 42 6f 6f 6b |ht (c) Y|ear Book|
|00005b20| 20 4d 65 64 69 63 61 6c | 20 50 75 62 6c 69 73 68 | Medical| Publish|
|00005b30| 65 72 73 2c 20 49 6e 63 | 2e 2c 20 31 39 38 39 0d |ers, Inc|., 1989.|
|00005b40| 0a 0d 0a 31 39 38 39 20 | 59 65 61 72 20 42 6f 6f |...1989 |Year Boo|
|00005b50| 6b 20 6f 66 20 50 65 64 | 69 61 74 72 69 63 73 20 |k of Ped|iatrics |
|00005b60| 28 52 29 0d 0a 0d 0a 43 | 68 61 70 74 65 72 20 36 |(R)....C|hapter 6|
|00005b70| 2d 2d 4e 65 75 72 6f 6c | 6f 67 79 20 61 6e 64 20 |--Neurol|ogy and |
|00005b80| 50 73 79 63 68 69 61 74 | 72 79 0d 0a 0d 0a 2d 2d |Psychiat|ry....--|
|00005b90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005ba0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005bb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005bc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005bd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 0d 0a |--------|------..|
|00005be0| 50 72 65 64 6e 69 73 6f | 6e 65 20 54 72 65 61 74 |Predniso|ne Treat|
|00005bf0| 6d 65 6e 74 20 69 6e 20 | 44 75 63 68 65 6e 6e 65 |ment in |Duchenne|
|00005c00| 20 4d 75 73 63 75 6c 61 | 72 20 44 79 73 74 72 6f | Muscula|r Dystro|
|00005c10| 70 68 79 3a 20 20 4c 6f | 6e 67 2d 54 65 72 6d 20 |phy: Lo|ng-Term |
|00005c20| 42 65 6e 65 66 69 74 0d | 0a 0d 0a 44 65 53 69 6c |Benefit.|...DeSil|
|00005c30| 76 61 20 53 2c 20 44 72 | 61 63 68 6d 61 6e 20 44 |va S, Dr|achman D|
|00005c40| 42 2c 20 4d 65 6c 6c 69 | 74 73 20 44 2c 20 4b 75 |B, Melli|ts D, Ku|
|00005c50| 6e 63 6c 20 52 57 0d 0a | 28 4a 6f 68 6e 73 20 48 |ncl RW..|(Johns H|
|00005c60| 6f 70 6b 69 6e 73 20 55 | 6e 69 76 29 0d 0a 41 72 |opkins U|niv)..Ar|
|00005c70| 63 68 20 4e 65 75 72 6f | 6c 20 34 34 3a 38 31 38 |ch Neuro|l 44:818|
|00005c80| 2d 38 32 32 2c 20 41 75 | 67 75 73 74 20 31 39 38 |-822, Au|gust 198|
|00005c90| 37 0d 0a 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |7..-----|--------|
|00005ca0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005cb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005cc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005cd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005ce0| 2d 2d 2d 0d 0a 0d 0a 41 | 62 73 74 72 61 63 74 0d |---....A|bstract.|
|00005cf0| 0a 0d 0a 20 20 20 20 20 | 41 6c 74 68 6f 75 67 68 |... |Although|
|00005d00| 20 74 68 65 20 67 65 6e | 65 74 69 63 20 62 61 73 | the gen|etic bas|
|00005d10| 69 73 20 6f 66 20 44 75 | 63 68 65 6e 6e 65 27 73 |is of Du|chenne's|
|00005d20| 20 6d 75 73 63 75 6c 61 | 72 20 64 79 73 74 72 6f | muscula|r dystro|
|00005d30| 70 68 79 20 28 44 4d 44 | 29 20 68 61 73 0d 0a 62 |phy (DMD|) has..b|
|00005d40| 65 63 6f 6d 65 20 62 65 | 74 74 65 72 20 75 6e 64 |ecome be|tter und|
|00005d50| 65 72 73 74 6f 6f 64 20 | 69 6e 20 72 65 63 65 6e |erstood |in recen|
|00005d60| 74 20 79 65 61 72 73 2c | 20 6e 6f 20 65 66 66 65 |t years,| no effe|
|00005d70| 63 74 69 76 65 20 6d 65 | 64 69 63 61 6c 20 74 72 |ctive me|dical tr|
|00005d80| 65 61 74 6d 65 6e 74 20 | 69 73 0d 0a 63 75 72 72 |eatment |is..curr|
|00005d90| 65 6e 74 6c 79 20 61 76 | 61 69 6c 61 62 6c 65 2e |ently av|ailable.|
|00005da0| 20 20 4d 75 73 63 75 6c | 61 72 20 77 65 61 6b 6e | Muscul|ar weakn|
|00005db0| 65 73 73 20 69 73 20 69 | 6e 65 76 69 74 61 62 6c |ess is i|nevitabl|
|00005dc0| 79 20 70 72 6f 67 72 65 | 73 73 69 76 65 20 69 6e |y progre|ssive in|
|00005dd0| 20 61 6c 6c 20 63 61 73 | 65 73 2e 0d 0a 49 6e 20 | all cas|es...In |
|00005de0| 31 39 37 34 2c 20 74 68 | 65 20 72 65 73 75 6c 74 |1974, th|e result|
|00005df0| 73 20 77 65 72 65 20 72 | 65 70 6f 72 74 65 64 20 |s were r|eported |
|00005e00| 6f 66 20 61 20 70 69 6c | 6f 74 20 73 74 75 64 79 |of a pil|ot study|
|00005e10| 20 6f 6e 20 74 68 65 20 | 74 68 65 72 61 70 65 75 | on the |therapeu|
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|00005e30| 70 72 65 64 6e 69 73 6f | 6e 65 20 69 6e 20 74 68 |predniso|ne in th|
|00005e40| 65 20 74 72 65 61 74 6d | 65 6e 74 20 6f 66 20 44 |e treatm|ent of D|
|00005e50| 4d 44 2e 20 49 6e 20 74 | 68 69 73 20 72 65 70 6f |MD. In t|his repo|
|00005e60| 72 74 2c 20 74 68 65 20 | 6c 6f 6e 67 2d 74 65 72 |rt, the |long-ter|
|00005e70| 6d 20 72 65 73 75 6c 74 | 73 20 6f 66 0d 0a 70 72 |m result|s of..pr|
|00005e80| 65 64 6e 69 73 6f 6e 65 | 20 69 6e 20 74 68 65 20 |ednisone| in the |
|00005e90| 74 72 65 61 74 6d 65 6e | 74 20 6f 66 20 44 4d 44 |treatmen|t of DMD|
|00005ea0| 20 61 72 65 20 72 65 70 | 6f 72 74 65 64 2e 0d 0a | are rep|orted...|
|00005eb0| 20 20 20 20 20 54 68 65 | 20 73 74 75 64 79 20 70 | The| study p|
|00005ec0| 6f 70 75 6c 61 74 69 6f | 6e 20 63 6f 6e 73 69 73 |opulatio|n consis|
|00005ed0| 74 65 64 20 6f 66 20 31 | 36 20 70 72 65 64 6e 69 |ted of 1|6 predni|
|00005ee0| 73 6f 6e 65 2d 74 72 65 | 61 74 65 64 20 44 4d 44 |sone-tre|ated DMD|
|00005ef0| 20 70 61 74 69 65 6e 74 | 73 20 61 6e 64 20 33 38 | patient|s and 38|
|00005f00| 0d 0a 63 6f 6e 74 72 6f | 6c 20 44 4d 44 20 70 61 |..contro|l DMD pa|
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|00006370| 20 20 20 20 20 54 72 65 | 61 74 6d 65 6e 74 20 77 | Tre|atment w|
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|000063c0| 0a 6f 66 20 44 4d 44 2c | 20 70 65 72 6d 69 74 74 |.of DMD,| permitt|
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